Soft Matter published our article (2025): Ravid et al.: Coupling Anisotropic Curvature and Nematic Order: Mechanisms of Membrane Shape Remodeling. In the article we studied theoretically how anisotropic curved membrane components (CMCs), i.e. curved nanodomains, control vesicle morphology through curvature sensing, nematic alignment, orientational ordering, topological defects and volume constraints (the concept introduced by our collaborator Veronika Kralj-Iglič in 1990s). By comparing arc-shaped and saddle-shaped CMCs, we identify a rich phase diagram of vesicle shapes. For fully CMC-covered vesicles, arc-shaped CMCs drive a pearling-to-cylinder transition as nematic interactions strengthen, while on partially CMC-covered vesicles the saddle-shaped CMCs stabilize necks between two convex membrane regions without CMCs. By investigating the in-plane nematic field, we find that topological defects consistently localize to high-curvature regions, revealing how intrinsic and deviatoric curvature effects cooperate in membrane remodeling. These findings establish a unified framework for understanding how proteins and lipid (nano)domains with anisotropic intrinsic curvature shape cellular structures—from organelle morphogenesis to global cell shape. Link, PDF.